Colchicine/traditional uses | Mode of action | Mode of administration | Doses | Toxicity/side effects | References | |
---|---|---|---|---|---|---|
Alkaloid from Colchicum autumnale | Powerful spindle poison anti-inflammatory used to treat a variety of conditions like gout, familial Mediterranean fever, pericarditis | Accumulates in leucocytes, interfering with leukocyte movement and degranulation, by binding tubulins, inhibits microtubule production | Oral drug delivery is unavailable the intravenous administration route is employed in dermatological problems, the topical pathway has been examined, and evidence of its effectiveness has been found | 0.5–2 mg/daily per day, given once, twice, or three times a day | Gastrointestinal symptoms renal failure bone marrow suppression arrhythmias heart failure |