Table 2 Role of PTENP1 in different non-malignant conditions according to cell line studies
Disorders | Interaction | Cell line | Function | References |
|---|---|---|---|---|
Alcohol-induced osteopenia | PTEN and Akt/GSK3β/β-catenin signaling | Human BMSCs (hBMSCs) | Ethanol treatment: ↑ PTEN and PTENP1 levels and ↓ Akt/GSK3β/β-catenin signaling ∆ PTEN: ↓ ethanol-induced suppression of bone formation and antiosteogenic effect of ethanol | [32] |
Insulin resistance | miR-499-5p/ PTEN axis | Murine liver cell line NCTC1469 | ↑↑ PTEN: ↓ Akt/GSK activation and glycogen synthesis | [33] |
Osteoporosis | miR-214/ PTEN axis, 3 K/AKT/NF-kB signaling pathway | RAW 264.7 macrophages | ↑↑ PTENP1: ↓ ANKL- induced osteoclast differentiation BY inhibiting 3 K/AKT/NF-kB signaling pathway | [34] |
Sepsis-associated cardiac dysfunction | miR-106b-5p | H9C2 | Matrine administration: ↓ expression of PTENP1 and inflammation, ↑ H9C2 viability | [35] |
Spinal cord injury | miR-21, miR-19b and PTEN | SH-SY5Y and U251 cells | ∆ PTENP1: ↑ apoptosis, miR-21, miR-19b and ↓ cell viability | [36] |