Table 3 PTENP1 role in different disorders based on animal studies

Bladder cancer

5 week-old male nude mice injected with EJ cell lines

↑↑ PTENP1: ↓ tumor weight, tumor volume and tumor size

[11]

Esophageal carcinoma

4 week-old male nude mice injected with Eca109 cells transfected with PTENP1 3′UTR or NC

↑↑ PTENP1: ↓ tumorigenesis

[21]

Head and neck squamous cell carcinoma

4-week-old male nude mice

↑↑ PTENP1: ↓ tumorigenesis

[25]

Hepatocellular carcinoma

4 week-old BALB/c nude mouse

∆ miR-21: ↓ tumor growth and size, ↑ PTEN, PTENp1, TET1, TET2 and TET3

[26]

4 week-old male immune-deficient nude mice (BALB/c-nu)

↑↑ PTENP1: ↓ tumor weight and tumor volume

[27]

6-8-weeks-old BALB/c nude mic were injected with Mahlavu cells

↑↑ PTENP1: ↓ tumor growth, intratumoral cell proliferation, and angiogenesis, ↑ apoptosis, autophagy

[28]

Oral squamous cell carcinoma

5 -week-old female BALB/C nude mice

mice were injected with Tca-8113 cells transfected with LV-miR-21 plus LV-PTEN and LV-PTENp1

↑↑ PTENP1: ↓ tumorigenesis

[30]

Renal cell carcinoma

Nude mice were injected with ACHN cells transfected with vector control or PTENP1

↑↑ PTENP1: ↑ sensitivity of ccRCC cells to cisplatin and gemcitabine

[31]

Alcohol-induced osteopenia

40 8-week-old male specific SPF and SD rats

∆ PTEN: ↓ ethanol-induced osteopenia

[32]

Insulin resistance

5 db/db mice and 5 age-matched wild-type (WT) mice

↑↑ PTENP1: ↑ hepatic insulin resistance

[33]

Osteoporosis

8-week-old female C57BL/6 mice

Levels of PTENP1 and PTEN were down-regulated in CS-F- and

RANKL-induced bone marrow mononuclear cell.

[34]

Spinal cord injury

Rats in sham group and SCI, SCI + exosomes, and SCI + exosomes + PTENP1-shRNA groups

Treatment with exosomes + PTENP1-shRNA: ↓ PTEN expression

PTENP1 participates in the recovery of SCI through regulation of miR-19b and miR-21.

[36]