Table 1 Functional roles of the NEAT1/miRNA/transcription factor axes in colorectal cancer
NEAT1/miRNA/transcription factor | Cell line (in vitro) | Animal model (in vivo) | Patients-derived tissue | Si-lncRNA- targeted therapy | Cancer cell initiation (proliferation) | Cancer cell progression | Cancer cell metastasis | Cancer cell apoptosis | Refs. |
|---|---|---|---|---|---|---|---|---|---|
MiR-34a/SIRT1/Wnt/β-catenin | ✓ | – | ✓ | ✓ | – | ✓ | ✓ | – | [60] |
MiR-185-5p/IGF2 | ✓ | – | ✓ | ✓ | – | ✓ | – | – | [65] |
MiR-495-3p/CDK6 | ✓ | ✓ | – | ✓ | ✓ | ✓ | – | ✓ | [66] |
MiR-193a-3p | ✓ | ✓ | ✓ | ✓ | – | ✓ | – | – | [68] |
MiR-205-5p/VEGFA | ✓ | – | ✓ | ✓ | ✓ | ✓ | – | – | [69] |
MiR-196a-5p/GDNF | ✓ | – | – | ✓ | ✓ | – | – | – | [71] |
DDX5/Wnt/β-catenin | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | [74] |
MiR-150-5p/CPSF4 | ✓ | – | ✓ | ✓ | – | ✓ | – | ✓ | [76] |
MiR-138/SLC38A1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | – | ✓ | [78] |
KDM5A/Cul4A/Wnt/β-catenin | ✓ | ✓ | ✓ | ✓ | – | ✓ | – | – | [79] |
MiR-486 5p/NR4A1/Wnt/β-catenin | ✓ | – | ✓ | ✓ | ✓ | ✓ | – | ✓ | [85] |
MiR-193a-3p/KRAS | ✓ | – | ✓ | ✓ | ✓ | – | – | ✓ | [86] |
Akt | ✓ | – | ✓ | ✓ | ✓ | – | – | ✓ | [58] |
ALKBH5 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | [93] |
MiR-377-3p | ✓ | – | ✓ | ✓ | ✓ | – | – | ✓ | [99] |