Fig. 6

DCs induced by CD40 Ab and OK-432 activated the proliferation of cytotoxic T cells while suppressing the number of Tregs. A DCs induced by CD40 Ab and OK-432 stimulated the generation of cytotoxic T cells. T cells derived from three different sources (peripheral blood, spleen, and lung) were separately treated with different types of DCs. Compared with the control groups, the agent-treated groups showed an increasing number of CD3⁺ cells, while the combinational group displayed a significant proliferation. B DCs induced by CD40 Ab and OK-432 restrained the production of Tregs. The proliferation of Tregs originating from the three sources was suppressed by the four agents, especially in the combinational group. Value represents mean ± standard error of mean. P-value represents the comparison of control group versus tested groups