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Fig. 7 | Cancer Cell International

Fig. 7

From: CD40 monoclonal antibody and OK432 synergistically promote the activation of dendritic cells in immunotherapy

Fig. 7

CD40 Ab and OK-432 synergistically enhanced the secretion of stimulatory cytokines while inhibiting the secretion of inhibitory cytokines. A CTLs induced by CD40 Ab and OK-432 inhibited the production of IL-10. The inhibitory cytokine IL-10 was restrained in the agent-treated groups, while the combinational group showed a prominent suppression. B CTLs induced by CD40 Ab and OK-432 inhibited the production of TGF-β. The secretion of inhibitory cytokine TGF-β was blocked in the agent-treated groups; the combinational group showed a significant change. C CTLs induced by CD40 Ab and OK-432 improved the ratio of IL-12/IL-10. D CTLs induced by CD40 Ab and OK-432 augmented the generation of IL-12. Although the four agent-treated groups contributed to the enhancement of stimulatory cytokine IL-12, the combinational group exhibited an outstanding contribution. E CTLs induced by CD40 Ab and OK-432 augmented the secretion of IFN-γ. The four agents facilitated the increase in the production of stimulatory cytokine IFN-γ; the combinational group displayed an obvious advantage. Value represents mean ± standard error of mean. P-value represents the comparison of control group versus tested groups

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