Table 1 The relative amount of PDI isoforms (PDIome) in selected cancer cell lines
No | Cell line | PDI repertoire in cell lysates | Type of cancer | PDIA1 | PDIA3 | PDIA4 | PDIA6 | PDIA9 | PDIA10 | PDIA15 | PDIA16 | PDIA17 | PDIA18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | LNCaP | 1,3,4,6,9,10 | Prostate cancer | 0.14 ± 0.03 | 0.35 ± 0.06 | 0.07 ± 0.02 | 0.09 ± 0.01 | 0.12 ± 0.02 | 0.04 ± 0.00 | ||||
2 | PC-3 | 1,3,4,6,9,15,17 | 0.20 ± 0.03 | 0.33 ± 0.07 | 0.08 ± 0.02 | 0.13 ± 0.02 | 0.11 ± 0.03 | 0.03 ± 0.00 | 0.33 ± 0.05 | ||||
3 | Du-145 | 1,3,4,6,9,15,16 | 0.36 ± 0.04 | 0.28 ± 0.05 | 0.14 ± 0.01 | 0.17 ± 0.02 | 0.22 ± 0.02 | 0.04 ± 0.01 | 0.09 ± 0.02 | ||||
4 | TRAMP C-2 | 1,3,4,6,9,15 | 0.27 ± 0.09 | 0.37 ± 0.08 | 0.04 ± 0.02 | 0.13 ± 0.02 | 0.06 ± 0.00 | 0.05 ± 0.02 | |||||
5 | TRAMP C-1 | 1,3,4,6,9,15 | 0.27 ± 0.07 | 0.51 ± 0.02 | 0.06 ± 0.01 | 0.09 ± 0.01 | 0.04 ± 0.00 | 0.05 ± 0.01 | |||||
6 | Lovo | 1,3,4,6,9,15 | Colon cancer | 0.14 ± 0.07 | 0.39 ± 0.10 | 0.15 ± 0.05 | 0.09 ± 0.02 | 0.21 ± 0.08 | 0.06 ± 0.04 | ||||
7 | HT29 | 1,3,4,6,9,10,15,16,17 | 0.38 ± 0.05 | 0.62 ± 0.12 | 0.20 ± 0.04 | 0.21 ± 0.05 | 0.15 ± 0.03 | 0.03 ± 0.00 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.36 ± 0.10 | ||
8 | CaCO2 | PDI: 1,3,4,6,9,10,16 | 0.20 ± 0.03 | 0.27 ± 0.01 | 0.09 ± 0.01 | 0.19 ± 0.01 | 0.17 ± 0.04 | 0.03 ± 0.00 | 0.09 ± 0.00 | ||||
9 | 5637 | PDI:1,3,4,6,9,10 | Urinary/bladder cancer | 0.26 ± 0.08 | 0.35 ± 0.06 | 0.15 ± 0.02 | 0.11 ± 0.02 | 0.06 ± 0.01 | 0.02 ± 0.00 | ||||
10 | MDA MB 231 | PDI:1,3,4,6,9,15 | Breast cancer | 0.14 ± 0.03 | 0.17 ± 0.09 | 0.10 ± 0.04 | 0.16 ± 0.07 | 0.13 ± 0.03 | 0.05 ± 0.02 | ||||
11 | 67NR | PDI:1,3,6,15,16 | 0.13 ± 0.01 | 0.15 ± 0.03 | 0.14 ± 0.00 | 0.04 ± 0.00 | 0.12 ± 0.05 | ||||||
12 | MCF-7 | PDI:1,3,4,6,9,10,15,17,18 | 0.24 ± 0.09 | 0.13 ± 0.04 | 0.08 ± 0.01 | 0.15 ± 0.02 | 0.21 ± 0.05 | 0.04 ± 0.01 | 0.03 ± 0.00 | 0.25 ± 0.12 | 0.13 ± 0.03 | ||
13 | 4T1 | PDI:1,3,4,6,15 | 0.10 ± 0.03 | 0.33 ± 0.06 | 0.03 ± 0.00 | 0.18 ± 0.03 | 0.05 ± 0.01 | ||||||
14 | T47D | PDI:1,3,4,6,9,15,16,17 | 0.53 ± 0.09 | 0.39 ± 0.13 | 0.04 ± 0.02 | 0.10 ± 0.00 | 0.23 ± 0.02 | 0.05 ± 0.02 | 0.08 ± 0.00 | 0.63 ± 0.19 | |||
15 | LLC | PDI:1,3,4,6,15 | Lung cancer | 0.09 ± 0.03 | 0.18 ± 0.12 | 0.02 ± 0.00 | 0.10 ± 0.02 | 0.04 ± 0.00 | |||||
16 | NCI H1703 | PDI:1,3,4,6,9,15,16 | 0.19 ± 0.17 | 0.23 ± 0.10 | 0.04 ± 0.02 | 0.11 ± 0.02 | 0.15 ± 0.04 | 0.04 ± 0.00 | 0.12 ± 0.00 | ||||
17 | A549 | PDI:1,3,4,6,9,15,17 | 0.15 ± 0.01 | 0.14 ± 0.01 | 0.05 ± 0.01 | 0.15 ± 0.02 | 0.06 ± 0.01 | 0.03 ± 0.00 | 0.06 ± 0.00 | ||||
18 | A427 | PDI:1,3,4,6,9,15,16 | 0.14 ± 0.04 | 0.20 ± 0.03 | 0.11 ± 0.05 | 0.21 ± 0.01 | 0.07 ± 0.04 | 0.02 ± 0.00 | 0.07 ± 0.00 | ||||
19 | NCI-H358 | PDI:1,3,4,6,9,15,16,17,18 | 0.28 ± 0.12 | 0.26 ± 0.02 | 0.07 ± 0.00 | 0.15 ± 0.02 | 0.18 ± 0.06 | 0.04 ± 0.01 | 0.07 ± 0.00 | 0.14 ± 0.07 | 0.12 ± 0.00 | ||
20 | NCI H1299 | PDI: 1,3,6,9,15,16 | 0.02 ± 0.00 | 0.11 ± 0.01 | 0.08 ± 0.02 | 0.09 ± 0.01 | 0.03 ± 0.00 | 0.07 ± 0.00 | |||||
21 | A2780 | PDI:1,3,4,6,9,15,16 | Ovarian cancer | 0.10 ± 0.02 | 0.32 ± 0.11 | 0.12 ± 0.03 | 0.15 ± 0.01 | 0.10 ± 0.03 | 0.06 ± 0.00 | 0.13 ± 0.00 | |||
22 | HT1080 | PDI: 1,3,4,6,9,15,16 | Fibrosarcoma | 0.19 ± 0.03 | 0.27 ± 0.04 | 0.17 ± 0.03 | 0.17 ± 0.03 | 0.10 ± 0.03 | 0.04 ± 0.01 | 0.08 ± 0.00 |