Fig. 1
From: Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders
Schematic representation of MIR4435-2HG functions in CRC. Increased level of MIR4435-2HG blocks miR-206 which leads to elevation of YAP1 and enhanced cell invasion, migration, proliferation and chemoresistance. In HCT116R cells, the activation of Nrf2 pathway leads to drug resistance; however, knockdown of MIR4435-2HG sensetives cancer cell to chemotherapy through inhibition of Nrf2. Furthermore, MIR4435-2HG can increase CRC progression via promoted GLUT-1