Fig. 4
From: Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders
The role of MIR4435-2HG in the pathogenesis of ovarian and breast cancers. In ovarian cancer, MIR4435-2HG regulates migration, invasion and apoptosis through modulating the expression of CDK14. The effect of MIR4435-2HG is exerted via sponging miR-128-3p. In addition, MIR4435-2HG enhances the progression of ovarian cancer via activation of the TGF-β signaling pathway. In breast cancer, MIR4435-2HG sponges miR-22-3p and results in a subsequent increase in TMEM9B expression and tumorigenesis