From: A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
Tumor type | Target/ Regulator/ Signaling | Cell line | Function | References |
---|---|---|---|---|
Hepatocellular carcinoma | miR-194-5p, FOXA1 | LO2, HepG2, Hep3B, Huh7, SMMC-7721 | ∆ MCM3AP-AS1: ↓ proliferation, ↑ cell cycle arrest, ↑ apoptosis | [18] |
Prostate cancer | miR-876-5p, WNT5A | C4-2, PC-3, LNCaP, DU145, 22Rv1 | ∆ MCM3AP-AS1: ↓ proliferation, ↑ apoptosis | [19] |
miR-543-3p, SLC39A10, PTEN/Akt signaling pathway | PC-3, DU145, 22RV1, LNCaP, WPMY-1 | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion, ↑ cell cycle arrest, did not affect apoptosis | [20] | |
NPY1R, MAPK pathway | RWPE1, 22RV1, LNCaP, and DU145 | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion, ↑ apoptosis | [21] | |
Breast cancer | miR-28-5p, CENPF | MCF-10A, MCF-7, BT-549, MDA-MB-468, HS578 T | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion | [26] |
Cervical cancer | miR-93 | C-33A, SiHa | ↑ MCM3AP-AS1: ↓ proliferation | [22] |
Colorectal cancer | miR-545, CDK4 | CR4 | ↑ MCM3AP-AS1: ↑ proliferation, ↓ G1 arrest | [23] |
miR-599, ARPP19 | HCT-116, SW620, SW480, LoVo, NCM460, 293 T | ↑ MCM3AP-AS1: ↑ proliferation, ↑ migration | [24] | |
miR‐193a‐5p, SENP1 | HCT‐8, HCT116, LoVo, HT29, and SW620 | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion | [25] | |
Oral squamous cell carcinoma | miR-363-5p | HOK, SCC-9, SCC-15, CAL-27 | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion | [27] |
miR-204-5p, FOXC1 | HN-6, SCC-9 | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion | [28] | |
Papillary thyroid cancer | miR-211-5p, SPARC | TPC-1, HTH83, 8505C, SW1736, BCPAP | ∆ MCM3AP-AS1: ↓ proliferation, ↓ migration, ↓ invasion | [29] |
Lymphoma | miR-15a, EIF4E | Daudi, Namalwa | ∆ MCM3AP-AS1: ↓ proliferation, ↑ apoptosis, ↑ sensitivity to doxorubicin | [30] |
Gastric cancer | miR-708-5p, SGC-7901 | GES-1, MGc-803, SGC-7901 | ∆ MCM3AP-AS1: ↓ proliferation, ↑ apoptosis | [31] |
miR-138, FOXC1 | AGS, MKN45, NCI-N87, SNU638, GES-1, 293 T | ∆ MCM3AP-AS1: ↑ CDDP sensitivity | [32] | |
Pancreatic cancer | miR-138-5p, FOXK1 | HPDE6-C7, PANC-1, BxPC-3, MIA PaCa-2, Capan-2, AsPC-1, HEK-293 | ↑ MCM3AP-AS1: ↑ proliferation, ↑ migration, ↑ invasion | [33] |
Nasopharyngeal carcinoma | miR-34a | FNA, C666-1, 13-9B | ↑ MCM3AP-AS1: ↑ proliferation, ↓ apoptosis | [34] |
Clear cell renal cell carcinoma | DPP4, E2F1 | 786-O, Caki-1, UT14, UT48 HK-2 | ↑ MCM3AP-AS1: ↑ proliferation, ↑ angiogenesis, ↑ inflammatory responses | [35] |
Glioblastoma | miR-211, KLF5, AGGF1, PI3K/AKT and ERK1/2 signaling pathways | hCMEC/D3, HEK293T | ∆ MCM3AP-AS1: ↓ viability, ↓ migration, ↓ tube formation, ↓ angiogenesis | [36] |
Lung cancer | miR‐340‐5p, KPNA4, YY1 | A549, H1299, H596, H520 | ∆ MCM3AP-AS1: ↓ angiogenesis, ↓ migration | [37] |
miR-148a, ROCK1 | SHP-77 | ∆ MCM3AP-AS1: ↓ migration, ↓ invasion | [38] | |
miR-195-5p, E2F3 | A549, H358, H1299, H460, H226, BEAS-2B | ↑ MCM3AP-AS1: ↑ proliferation, ↑ migration, ↑ invasion ↓ apoptosis | [40] | |
Endometrioid carcinoma | miR-126, VEGF | HEC-1 | ↑ MCM3AP-AS1: ↑ migration, ↑ invasion | [39] |