From: A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
Tumor type | Samples | Expression (tumor vs. Normal) | Kaplan–Meier analysis (impact of MCM3AP-AS1 up-regulation) | Univariate/multivariate cox regression | Association of MCM3AP-AS1expression with clinicopathologic characteristics | Quantification method | Normalization method | References |
---|---|---|---|---|---|---|---|---|
Hepatocellular carcinoma (HCC) | 80 pairs of HCC and ANCTs (80 patients) | Up | Poorer OS | _ | Advanced tumor stages, tumor size, high tumor grade, and advanced TNM stages | qRT-PCR | 2−ΔΔCt Method (normalized by GAPDH and U6) | [18] |
GSE65485 (50 HCC tissues and 5 ANCTs) and GSE54236 | Up | _ | _ | _ | _ | _ | ||
GEO databases: daGSE29721, GSE40367, GSE62232, GSE36915, GSE74618 | Up | Shorter OS | _ | _ | _ | _ | [42] | |
Prostate cancer (PCa) | 30 pairs of PCa and ANCTs (30 patients) | Up | _ | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | [19] |
TCGA analysis: _ | Up | Shorter DFS | _ | _ | _ | _ | ||
64 pairs of PCa and ANCTs (64 patients) | Up | Poorer OS | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | [20] | |
GEO analysis: GSE3868 | Up | _ | _ | _ | _ | _ | [21] | |
TCGA analysis: | Up | _ | _ | _ | _ | _ | ||
46 pairs of PCa and ANCTs (46 patients) | Up | _ | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | ||
GEO analysis: GSE32269, GSE26964 | Up | _ | _ | PCa bone metastasis by regulating immune microenvironment, especially M2 macrophages | _ | _ | [44] | |
TCGA analysis: 490 PRAD patients | Up | _ | _ | _ | _ | |||
Breast cancer (BC) | 102 pairs of BC and ANCTs (102 patients) | Up | _ | _ | Estrogen or progesterone receptor expression | qRT-PCR | 2−ΔΔCt method | [43] |
Cervical cancer | 64 pairs of CSCC and ANCTs (64 patients) | Down | Higher OS | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | [22] |
Colorectal cancer (CRC) | 60 pairs of CRC and ANCTs (60 patients) | Up | Lower OS | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | [23] |
30 pairs of CRC and ANCTs (30 patients) | Up | _ | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH) | [24] | |
131 pairs of CRC and ANCTs (131 patients) | Up | _ | _ | Larger tumor size | qRT-PCR | 2−ΔΔCt method (normalized by β‐actin) | [25] | |
TCGA database and GEO GSE21510 database | Up | _ | _ | _ | _ | _ | ||
Oral squamous cell carcinoma (OSCC) | 36 pairs of OSCC and ANCTs (36 patients) | Up | _ | _ | Clinical stage and lymph node metastasis | qRT-PCR | 2-ΔΔCt method (normalized by U6) | [27] |
Papillary thyroid cancer (PTC) | 68 pairs of papillary thyroid cancer samples and ANCTs (68 patients) | Up | Lower OS | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH and U6) | [29] |
Lymphoma | 41 pairs of papillary thyroid cancer tissues and ANCTs (41 patients) | Up | Lower OS | _ | Tumor size, Tumor stage | qRT-PCR | _ | [30] |
Pancreatic cancer (PC) | 86 pairs of PC and ANCTs (86 patients) | Up | Shorter OS | _ | _ | qRT-PCR | 2−ΔΔCt method (normalized by GAPDH and U6) | [33] |
Nasopharyngeal carcinoma (NPC) | 55 pairs of NPC and ANCTs (55 patients) | Up | Lower OS | _ | _ | qRT-PCR | triplicate and 2−ΔΔCT method (normalized by GAPDH) | [34] |
Clear cell renal cell carcinoma (ccRCC) | GEO GSE15641 database | Up | _ | _ | _ | _ | _ | (35) |
78 pairs of ccRCC and ANCTs (78 patients) | Up | Shorter OS | Expression of MCM3AP-AS1 was an independent prognostic factor for ccRCC patients | Tumors size > 7 cm | qRT-PCR | Triplicate and 2−ΔΔCT method (normalized by β-actin) | ||
Lung cancer | 60 pairs of SCLC and ANCTs (60 patients) | Up | Lower OS | _ | _ | qRT-PCR | Triplicate and 2−ΔΔCT method (normalized by GAPDH) | [38] |
63 pairs of NSCLC and ANCTs (63 patients) | Up | Lower OS | _ | _ | qRT-PCR | 2−ΔΔCT method (normalized by GAPDH) | (40) | |
Endometrioid carcinoma (EC) | 60 pairs of EC and ANCTs (60 patients) | Up | Poor OS and PFS | _ | _ | qRT-PCR | 2−ΔΔCT method (normalized by GAPDH) | [39] |