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Table 3 Abnormal levels of MCM3AP-AS1 in clinical samples

From: A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression

Tumor type

Samples

Expression (tumor vs. Normal)

Kaplan–Meier analysis (impact of MCM3AP-AS1 up-regulation)

Univariate/multivariate cox regression

Association of MCM3AP-AS1expression with clinicopathologic characteristics

Quantification method

Normalization method

References

Hepatocellular carcinoma (HCC)

80 pairs of HCC and ANCTs (80 patients)

Up

Poorer OS

_

Advanced tumor stages, tumor size, high tumor grade, and advanced TNM stages

qRT-PCR

2−ΔΔCt Method (normalized by GAPDH and U6)

[18]

GSE65485 (50 HCC tissues and 5 ANCTs) and GSE54236

Up

_

_

_

_

_

GEO databases: daGSE29721,

GSE40367, GSE62232, GSE36915, GSE74618

Up

Shorter OS

_

_

_

_

[42]

Prostate cancer (PCa)

30 pairs of PCa and ANCTs

(30 patients)

Up

_

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

[19]

TCGA analysis: _

Up

Shorter DFS

_

_

_

_

64 pairs of PCa and ANCTs

(64 patients)

Up

Poorer OS

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

[20]

GEO analysis: GSE3868

Up

_

_

_

_

_

[21]

TCGA analysis:

Up

_

_

_

_

_

46 pairs of PCa and ANCTs

(46 patients)

Up

_

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

GEO analysis: GSE32269, GSE26964

Up

_

_

PCa bone metastasis by regulating immune microenvironment, especially M2 macrophages

_

_

[44]

TCGA analysis: 490 PRAD patients

Up

_

_

_

_

Breast cancer (BC)

102 pairs of BC and ANCTs (102 patients)

Up

_

_

Estrogen or progesterone receptor expression

qRT-PCR

2−ΔΔCt method

[43]

Cervical cancer

64 pairs of CSCC and ANCTs (64 patients)

Down

Higher OS

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

[22]

Colorectal cancer (CRC)

60 pairs of CRC and ANCTs (60 patients)

Up

Lower OS

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

[23]

30 pairs of CRC and ANCTs (30 patients)

Up

_

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH)

[24]

131 pairs of CRC and ANCTs (131 patients)

Up

_

_

Larger tumor size

qRT-PCR

2−ΔΔCt method (normalized by β‐actin)

[25]

TCGA database and GEO GSE21510 database

Up

_

_

_

_

_

Oral squamous cell carcinoma (OSCC)

36 pairs of OSCC and ANCTs (36 patients)

Up

_

_

Clinical stage and lymph node metastasis

qRT-PCR

2-ΔΔCt method

(normalized by U6)

[27]

Papillary thyroid cancer (PTC)

68 pairs of papillary thyroid cancer samples and ANCTs (68 patients)

Up

Lower OS

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH and U6)

[29]

Lymphoma

41 pairs of papillary thyroid cancer tissues and ANCTs (41 patients)

Up

Lower OS

_

Tumor size, Tumor stage

qRT-PCR

_

[30]

Pancreatic cancer (PC)

86 pairs of PC and ANCTs (86 patients)

Up

Shorter OS

_

_

qRT-PCR

2−ΔΔCt method (normalized by GAPDH and U6)

[33]

Nasopharyngeal carcinoma (NPC)

55 pairs of NPC and ANCTs (55 patients)

Up

Lower OS

_

_

qRT-PCR

triplicate and 2−ΔΔCT method (normalized by GAPDH)

[34]

Clear cell renal cell carcinoma (ccRCC)

GEO GSE15641 database

Up

_

_

_

_

_

(35)

78 pairs of ccRCC and ANCTs (78 patients)

Up

Shorter OS

Expression of MCM3AP-AS1 was an independent prognostic factor for ccRCC patients

Tumors size > 7 cm

qRT-PCR

Triplicate and 2−ΔΔCT method (normalized by β-actin)

Lung cancer

60 pairs of SCLC and ANCTs (60 patients)

Up

Lower OS

_

_

qRT-PCR

Triplicate and 2−ΔΔCT method (normalized by GAPDH)

[38]

63 pairs of NSCLC and ANCTs (63 patients)

Up

Lower OS

_

_

qRT-PCR

2−ΔΔCT method (normalized by GAPDH)

(40)

Endometrioid carcinoma (EC)

60 pairs of EC and ANCTs (60 patients)

Up

Poor OS and PFS

_

_

qRT-PCR

2−ΔΔCT method (normalized by GAPDH)

[39]

  1. ANCTs adjacent non-cancerous tissues, OS overall survival, DFS disease-free survival, TNM tumor‐node‐metastasis, PRAD prostate adenocarcinoma, SCLC small cell lung cancer, NSCLC non-small cell lung cancer, PFS progression-free survival