Fig. 1

FA metabolic events and upregulated carcinogenetic signals. Scheme showing cellular fatty acid metabolic events, including FA transport, FA storage, lipolysis, β-oxidation, and de novo FA synthesis. Uptake of extracellular FAs is mediated by FA transport protein (FATP), CD36, and FABPs. The intracellular FAs form FA pool, and the FAs are either stored as lipids droplets or activated by reaction with CoA to form fatty-acyl-CoA (FACoA) for β-oxidation in mitochondria. The de novo FA synthesis begins with acetyl-CoA which is either derived from mitochondria or converted from citrate by ACLY. Acetyl-CoA is then converted to malonyl-CoA by ACC, and malonyl-CoA is further converted to FA by FASN. Red pentagon: upregulated FA metabolic signals contribute to carcinogenesis