Fig. 2
From: Lipid metabolism in tumor microenvironment: novel therapeutic targets
Pathways of cholesterol synthesis and regulation of carcinogenetic signals. Scheme showing cholesterol synthetic pathways, carcinogenetic signaling regulation in mevalonate pathway, and the cholesterol oxygenated metabolites feedback on cholesterol synthesis and efflux/influx. PI3K/AKT/mTOR and mutant p53 activate the mevalonate pathway via upregulation of SREBP, while Statins and LXR can inhibit cholesterol synthesis. 27HC negatively feedbacks on cholesterol synthesis and efflux/influx but miR-33a decreases cholesterol efflux. MVK mevalonate kinase; MVD mevalonate diphosphate decarboxylase; PMVK phosphomevalonate kinase; FPPS farnesylpyrophosphate synthase; SQS squalene synthase; SQLE squalene epoxidase; LSS lanosterol synthase