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Fig. 2 | Cancer Cell International

Fig. 2

From: Regulatory function of DNA methylation mediated lncRNAs in gastric cancer

Fig. 2

The roles of lncRNAs in cancer. There are main layers of the roles of lncRNAs in cancer. First of all, lncRNAs are able to activate or inhibit their neighboring genes, similarly playing on transactivation or transinhibition of other genes. Once the condition happened, can the genes expression swarm with fatal errors not least because of disordered expression. Secondly, it is inescapable that lncRNAs are bound to exert an influence on the post-transcriptional event, like mRNA splicing, which is regarded as a kind of regulator to interact with splice-osome. Otherwise, their chromatin modification roles also deserve attention, for example, H3K27 trimethylation is closely related to the abnormal proliferation of cancer cells. Moreover, lncRNAs are not confined to the nucleus, for their roles even extend to the cytoplasm, from modulation of translation that can act on ribosomes to signaling protein interaction that has become a vital part of cancer. Overall, lncRNAs are already having broad effects well beyond this RNA itself. And the roles of lncRNAs are being lightened as their researches are uncovered gradually

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