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Table 1 The influences of DNA methylation in LncRNAs’ in gastric cancer

From: Regulatory function of DNA methylation mediated lncRNAs in gastric cancer

LncRNA

Pattern

Expression level

Mechanism

Outcomes

Uc.160+ 

Hypermethylation

↓

Src/MEK/ERK and p38 pathway

Metastasis, carcinogenesis

Linc00086

Hypermethylation

↓

ERK1/2 signaling pathway

Progression

SPRY4-1T1

Hypermethylation

↓

EMT

Metastasis, invasion

C50rf66-AS1

Hypermethylation

↓

Abrogating Sp1 binding

Proliferation, invasion

MEG3

Hypermethylation

↓

–

Progression, prognosis

AFDN-DT

Hypermethylation

↓

–

Proliferation, metastasis

LOC100130476

Hypermethylation

↓

–

Progression, diagnosis, prognosis