Fig. 6

Immune-related characteristics of patients with COAD in the ATOH1-H and ATOH1-L groups. A Scatter plots of ATOH1 expression and immune-related genes. B Composition ratio of TCGA subtype and immune subtype in ATOH1-H and ATOH1-L groups. The TCGA molecular subtype was determined based on 921 cases of gastrointestinal (GI) tract adenocarcinomas, GI.CIN (chromosomal instability), GI.GS (genome stable), GI.HM-SNV (hypermutated-SNV), GI.HM-indel (hypermutated-SNV) [52]. Six immune subtypes refer to C1 (wound healing), C2 (IFN-g dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), C6 (TGF-b dominant) [41]. C Correlation matrix heatmap of the PanImmune Feature. The connected lines represent the correlation between ATOH1 and the PanImmune Feature. The solid lines indicate positive correlations, and dashed lines indicate negative correlations. The colors represent the magnitude of the p-value in the correlation analysis. The thickness of the connecting line represents the magnitude of the correlation coefficient. D Distribution of the DAPs on the chromosomes of the ATOH1-H and ATOH1-L groups. The line segments on the chromosomes represent peaks, while the colors represent the logFC values of the differential peaks. The position of immune signal genes for the prognosis-related immune cells is marked next to the chromosome. E. Box plot showing TMB in the ATOH1-H and ATOH1-L groups. Scatter plot showing the relationship between ATOH1 expression and TMB