Fig. 11
From: The autophagy inducer trehalose stimulates macropinocytosis in NF1-deficient glioblastoma cells
Trehalose induces cell death by methuosis in U373-MG cells. U373-MG cells were untreated (A) or treated with 90 mM trehalose for 10–14 days (B, C); phase-contrast microscopy images of live cells were obtained from the plates used for clonogenic assay (before fixation and staining). White arrows indicate less refringent large vacuoles, with dense material inside. Scale bar = 50 mm