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Fig. 1 | Cancer Cell International

Fig. 1

From: CircPDSS1 promotes the proliferation, invasion, migration, and EMT of breast cancer cell via regulating miR-320c/CKAP5 axis

Fig. 1

CircPDSS1 promotes the proliferation, migration, invasion and EMT of BC cells. A The expression of circPDSS1 in BC cell lines (MCF-7, MDA-MB-231, SKBR-3, BT-549 and BT-474) and normal mammary epithelial cell line (MCF-10A) was measured via qRT-PCR. B, C The expression of circPDSS1 and linear PDSS1 in ActD or RNase R-treated BC cells was analyzed at the time point 0, 4, 8, and 12 h via qRT-PCR. D CircPDSS1 expression in sh-circPDSS1#1/#2-transfected cells was detected by qRT-PCR. E, F CCK-8 and colony formation assays were employed to examine the proliferation of the transfected BC cells. G TUNEL assay was applied to test the apoptosis of BC cells. H, J Transwell, wound healing and IF assays were utilized to analyze the invasion, migration and EMT of the transfected BC cells. *P < 0.05, **P < 0.01. n.s.: no significance

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