Fig. 2From: Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment NAMPT in TIME. In the tumor immune microenvironment, eNAMPT can regulate the production of cytokines such as IL-1, IL-6, and TNF-α, inhibit anti-tumor immunity, promote tumor invasion and metastasis through M-CSF/SIRT-1/HIF-1/CXCR4 and TLR-4/ NF-KBBack to article page