Fig. 5

New types of therapy. A Microparticle MP can deliver NAMPT inhibitor GMX1778 to glioma cells in A directional manner and control its release amount to resist tumor by up-regulating PD-L1 expression, inhibiting m2-type macrophage generation, and collecting CD4 + and CD8 + T cells. B Encapsulation of exosomes protects siRNA from degradation, and modification of E3 aptamer can be directed to prostate cancer cells, and siRNA plays an anti-tumor role by silencing SIRT-6. C After the hybrid nanoparticles of silicon carbide (LSC) coated by lipid membrane enter the cell, LCS directionally binds to mitochondria and generates ROS under infrared light. ROS oxidizes NADH to NAD + and reduces ATP production, inhibiting p-glycoprotein (P-GP) from excreting chemotherapeutic drugs out of the cell, thus improving tumor drug resistance