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Fig. 2 | Cancer Cell International

Fig. 2

From: Identification of genes with high heterogeneity of expression as a predictor of different prognosis and therapeutic responses in colorectal cancer: a challenge and a strategy

Fig. 2

Enrichment of high and low heterogeneity genes as well as the relationship of high heterogeneity genes to clinical and genomic features. A Pathways related to identified genes with HHE based on MsigDB data. B The pathways related to genes with low heterogeneity of expression level between two cohorts TCGA and GSE39582 based on MsigDB data with FDR < 0.01. C, D Common mutations based on DNA-seq data and the type of mutation were shown in CRC samples. Venn diagram was used to identify a sample that has only one of the most common mutations including APC, KRAS, TP53, MUC16, and SYNE1. (E-I) Correlation of 132 identified genes with high heterogeneity of expression level with clinical and genomic characteristics in CRC samples based on the TCGA data. Linear model test was used to assess the differential expression and FDR < 0.01 was considered as statistical significance

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Cancer Cell International

ISSN: 1475-2867

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