Fig. 2

Pancancer expression pattern and biological and immunomodulatory function of TMSB10. A (Top) The distribution of sample-specific TMSB10 expression across each cancer type; (middle) bubble plots showing the correlation between TMSB10 and classical cancer pathways or genes. The color of the circle represents the correlation coefficient: red indicates a positive correlation, and blue indicates a negative correlation. (Down) The scatter plot shows the correlation between TMSB10 and classical cancer pathways or genes in LGG. Correlation between TMSB10 and B 28 tumor-associated immune cells calculated with the ssGSEA algorithm and correlation with (C) CAFs and D immunomodulators (immunoinhibitory, immunostimulatory and MHC molecules). The color indicates the correlation coefficient. The asterisks indicate a statistically significant p value calculated using Spearman correlation analysis. The statistical significance is indicated as follows: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001