Fig. 4From: METTL3 suppresses anlotinib sensitivity by regulating m6A modification of FGFR3 in oral squamous cell carcinomaLevels of METTL3 are inversely associated with anlotinib sensitivity in OSCC cells. A The cytotoxic effect of anlotinib in different OSCC cell lines using cell viability assay. B and C The mRNA and protein levels of METTL3 in different OSCC cell lines using qRT-PCR and western blotting. D Cell viability assay showed the cytotoxic ability of anlotinib was significantly increased (decreased of IC50) in METTL3-knockdown OSCC cells compared with control cells (24 h). E Cell apoptosis assay showed the ratio of apoptosis cells in anlotinib-treated (24 h) cells was significantly increased after METTL3 knockdown in SCC9 and SCC25 cells lines. *P < 0.05; **P < 0.01; ***P < 0.001Back to article page