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Fig. 4 | Cancer Cell International

Fig. 4

From: METTL3 suppresses anlotinib sensitivity by regulating m6A modification of FGFR3 in oral squamous cell carcinoma

Fig. 4

Levels of METTL3 are inversely associated with anlotinib sensitivity in OSCC cells. A The cytotoxic effect of anlotinib in different OSCC cell lines using cell viability assay. B and C The mRNA and protein levels of METTL3 in different OSCC cell lines using qRT-PCR and western blotting. D Cell viability assay showed the cytotoxic ability of anlotinib was significantly increased (decreased of IC50) in METTL3-knockdown OSCC cells compared with control cells (24 h). E Cell apoptosis assay showed the ratio of apoptosis cells in anlotinib-treated (24 h) cells was significantly increased after METTL3 knockdown in SCC9 and SCC25 cells lines. *P < 0.05; **P < 0.01; ***P < 0.001

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