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Fig. 7 | Cancer Cell International

Fig. 7

From: Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint

Fig. 7

Silencing of LINC00460 reduces the tumor growth of PC through anti-PD-1 therapy and enhances the sensitivity of PANC-1 cells to cytotoxicity of tumor-reactive T cells via regulating the miR-503-5p/ANLN axis. A The images of tumor xenograft with different treatments. B The tumor volumes were monitored at different time points. C The tumor weight in mice of each group after 2 weeks of injection. **P < 0.01 vs. the IgG + sh-NC group; ##P < 0.01 vs. the anti-PD-1 + sh-NC group. D Ki67 staining in PC tissues was measured by IHC assay (400 ×). E The sensitivity of PANC-1 cells to the cytotoxicity of tumor-reactive T cells in different treatments. **P < 0.01 vs. the sh-NC group; #P < 0.05, ##P < 0.01 vs. the sh-LINC00460 group

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Cancer Cell International

ISSN: 1475-2867

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