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Fig. 2 | Cancer Cell International

Fig. 2

From: Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC)

Fig. 2

DKK3 deletion mutant expression plasmids and their effect on cellular proliferation, invasion, and migration. a MTT assay revealed that DKK3 transfection resulted in significantly increased cellular proliferation, while that of DKK3ΔC1 transfectant or DKK3ΔC2 transfectant was quelled to the control level and that of DKK3ΔC1ΔC2 was significantly diminished compared to all group. b Cancer cell invasion was significantly elevated in DKK3 transfectants, whereas DKK3 ΔC1 is not. Transfection with DKK3ΔC2 and DKK3ΔC1ΔC2 significantly decreased cancer cell invasion. c The wound healing assay showed that transfection of DKK3, DKK3ΔC1 and DKK3ΔC2 significantly elevated cancer cell migration, and transfection of DKK3ΔC1ΔC2 showed suppressed cellular migration to the control level

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