Fig. 4

Models of DKK3 and peptides, and docking simulation. a The model of DKK3. The predicted structure; α-helix, β-sheet, CRD1, and CRD2, are colored in green, yellow, red, and blue, respectively. The number in α-helix, β-sheet means the corresponding amino acid (left). The surface was displayed in the model (center), together with the structures as ribbon (right). b Docking simulation results with the lowest energy are shown; #6 for CRD1 and #5 for CRD5. The enlarged illustration in the black frame shows the predicted binding sites