Fig. 5

Effects of the peptides on Akt phosphorylation. a Transfection of full-length DKK3 resulted in an elevated expression of DKK3, and administration of peptide reduced the phosphorylation of Akt, together with DKK3 expression in a dose-dependent manner. b Phosphorylation of Akt was elevated when full-length DKK3 was transfected, which was significantly suppressed by peptide. c The IC₅₀ for suppression of phosphor-Akt was calculated as 41.5 nM