Fig. 3

Prediction of RFS using the E2F-related gene signature of PCa patients in the MSKCC cohort. The distribution of risk scores (A) and disease statuses (B) in PCa patients, and the dashed line represents the median value of the risk score. The heatmap showed that the four identified genes, CDKN2C, CDKN3, RACGAP1, and RRM2, were highly expressed in PCa patients with high-risk scores compared to patients with low-risk scores (C), and patients with higher risk scores exhibited poorer RFS (D). The ROC curve analysis indicated the good performance of the E2F-related gene signature in RFS prediction (E), and the 1-, 3-, 5-, and 10-year time-dependent ROC curves indicated the good predictive value of the E2F-related gene signature (F)