From: Exosomal circular RNA: a signature for lung cancer progression
Circ-RNA | Number of clinical samples | Types of specimens | Animal model | Expression | Target Genes | Mechanisms | Functions | Refs |
---|---|---|---|---|---|---|---|---|
CircNOL10 | 61 pairs of cancerous and paracancerous lung tissue samples | A549, H1299, H226, H460, H661, SK-MES-1, BEAS-2B | Nude mice | Down | ESRP1, SCML, HN | – | Promotes SCLM1-mediated transcriptional regulation, hence suppressing LC development | [196] |
Circ0006916 | 49 patients | 16HBE-T, A549, H460, 16HBE | – | Down | miR-522-3p, TNRC6A, PHLPP1 | – | Upregulating PHLPP1 with miR-522-3p inhibits cellular proliferation and tumor growth | [197] |
hsa_circ_100395 | 69 pairs of LC tissues and normal tissues | A549, H460 | Nude mice | Down | miR-1228, TCF21 | miR‐1228/TCF21 axis | miRNA sponge | [198] |
CircPTK2 | 73 pairs of LC tissues and normal tissues | A549,H1299, H1650, SPC-A1, Calu3, H226, H520, SK-MES-1, BEAS-2B | Nude mice | Down | miR-429/miR-200b-3p, 3’-UTR of TIF1γ, TGF-β | – | Targeting TIF1 to reduce TGF- γ induced EMT as miR-429/miR-200b-3p sponges | [199] |
Circ_0001649 | 53 paired of tissue specimens | A549, H358, H1299, H1581, 16HBE | Nude mice | Down | miR-331-3p and miR-338-5p | Circ_0001649 miR-331-3p/miR-338-5p regulatory pathway | Represses LC development by sponging miR-331-3p and miR-338-5p | [200] |
Circ_103820 | 20 paracarcinoma and lung cancer pairs | SPCA1, A549, HEK-293 T | – | Down | miRNA-200b-3p, LATS2, SOCS6 | Circ_103820/miRNA-200b-3p axis | Lung cancer miR-200b-3p sponge modulates LATS2 and SOCS6 expression | [201] |
Circ-SLC7A6 | 110 pairs of NSCLC and precancerous normal tissues | A549, H460 | Nude mice | Down | miR-21 | Circ-SLC7A6/miR-21 axis | circ-SLC7A6 suppressed LC proliferation through sponging miR-21 | [202] |
CircPTPRA | NSCLC patients (n = 34) | H522, H23, H1755, BEAS-2B | Nude mice | Down | miR-96-5p, RASSF8 | miR-96-5p/RASSF8/E-cadherin pathway | prevents LC cells from undergoing EMT and spreading by sponging miR-96-5p | [203] |