Fig. 2

c-Rel, p65 and p50 link the HPV16 oncoprotein and two groups of HPV16rmiRNAs. A: Rel, Nfκb1 and Rela were regulated by HPV16 E5, they were increased by the increase of E5 and decreased by the decrease of E5; B: Rel, Nfκb1 and Rela were not regulated by HPV16 E6, Rel and Nfκb1 were decreased with the decrease of E6,but they were not changed when E6 overexpression; C: Rel, Nfκb1 and Rela were not regulated by HPV16 E7, Rel and Nfκb1 were decreased with the decrease of E7,but they were not changed when E7 overexpression. D: HPV16rmiRNAs were regulated by c-Rel, almost all these miRNAs increased when the shRel transfected in SiHa cells and decreased when the Rel OE transfected in C33-A cells; E: p65 regulate miR-133a-5p which increased when the shRela transfected in SiHa cells and decreased when the Rela OE transfected in C33-A cells; F: miR-299-5p,miR-329-3p, miR-369-5p, miR-495-3p, miR-376b-3p, miR-379-5p were modulated by p50,they increased when the shNFκb1 transfected in SiHa cells and decrease when the NFκb1 OE transfected in C33-A cells. *:P < 0.05