Fig. 3
From: NRP1 inhibition modulates radiosensitivity of medulloblastoma by targeting cancer stem cells
Effect of MR438 on NRP1 expression in heterotopic xenografts in nude mice. Representative images of NRP1 expression in tumors after irradiation and/or MR438 treatments A; scale bars represent 100 µm. The percentage of cells positive for NRP1 B for each condition was calculated with QuPath open software from approximately 5000 cells for 3 different images with wide field of observation from 3 different tumors. The analysis were performed at the experimental endpoint (corresponding to an average of 19 ± 3 days for mice of non-irradiated groups and 51 ± 8 days for mice of irradiated groups). *p < 0.05 versus CTL and #p < 0.05 versus RT; n = 6