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Fig. 6 | Cancer Cell International

Fig. 6

From: NRP1 inhibition modulates radiosensitivity of medulloblastoma by targeting cancer stem cells

Fig. 6

Effect of MR438 in combination with RT on intracerebellum DAOY growth and survival fraction after two weeks of treatment. Intracerebellum tumor visualized by in vivo bioluminescence imaging on day 50 post-tumor cell implantation for the RT group vs the RT + MR438 group (A). Tumor growth after two weeks of treatment (radiations: 10 × 2 Gy and/or administration of MR438: 10 mg/kg) B and survival fraction C were evaluated by bioluminescence. The percentage of cells positive for NRP1 D, E or CD15 F, G at 15 days post-treatment D, F or at the end point of the experiment E, G was quantified with QuPath open software from approximately 5000 cells for 3 different images with wide field of observation from 3 different tumors. *p < 0.05 versus CTL, **p < 0.01 versus CTL, #p < 0.05 versus RT; n = 7 per group for tumor growth and n = 3 per group for histological analysis

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