Fig. 1
From: Role of microRNA-34b-5p in cancer and injury: how does it work?
Mechanism of miR-34b-5p in the development of cancer. A Role of miR-34b-5p in colorectal cancer: LINC02418 promoted colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis. HuR bound to OIP5-AS1 and stabilized OIP5AS1 expression while miR-34b-5p inhibited the proliferation and invasion of CC cells by inhibiting the OIP5-AS1 and PI3K/Akt pathways. B Role of miR-34b-5p in bladder carcinoma: Exosomal LINC00355 derived from cancer-associated fibroblasts promoted bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis. B Role of miR-34b-5p in prostate carcinoma: The process of enhancement of anticancer activity of docetaxel by combination with Fuzheng Yiliu decoction in a mouse model of castration-resistant prostate cancer involved the regulation of miR-34b-5p and PI3K/Akt signaling pathways. D Role of miR-34b-5p in colitis-associated cancer: Inflammatory factors influenced the expression of c-MYC and CRL4DCAF4 E3 ligase activity by downregulating of miR-34b-5p to cause colitis-associated cancer. Role of miR-34b-5p in pancreatic ductal adenocarcinoma: Circular-RNA circBFAR promoted the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis