From: Role of microRNA-34b-5p in cancer and injury: how does it work?
Diseases | Gene, mRNA, signal channels, or proteins that may be involved | Variation of miR-34b-5p | Influencing mechanism, effect, or role of miR-34b-5p | References | |
---|---|---|---|---|---|
Ovarian function damage | Ras signaling pathway Rap1 signaling pathway Foxo signaling pathway Hippo signaling pathway MAPK signaling pathway Carcinogenic pathway | Down | Cell metabolism regulation post‐transcriptional Regulation of mRNA interleukin‐6‐mediated Signal transduction cell cycle Cell proliferation Differentiation and migration | Wang, W., et al., [72] | |
Ovarian cancer | Met gene c-met gene Bcl-2 gene p53 gene Myc gene Cdk6 gene | MET protein BCL-2 protein CDK4 protein | Down | Regulation of cell death Occurrence of epithelial ovarian cancer Development of epithelial ovarian cancer Metastatic clinical stage Proliferation and invasion Cell Proliferation Cell adhesion-independent growth | |
Spermatogenesis | c-Kit gene cdk6 gene Rbm44 gene Cdh3 gene | CDK6 protein C-KIT protein | Up in spermatogenesis Down in decreases in spermatocytes | Cell developmental processes mRNA transcription and regulation Cell cycle regulation Signal transduction Protein modification Semen concentration and motility regulation | Sree, S., et al., [76] Smorag, L., et al., [77] Eikmans, M., et al., [79] |
Placental function | BCL2 gene TP53 gene MYC gene CDKN1B/C gene VEGFA gene TNFSF10 gene ZEB1 gene | Up | Trophoblast proliferation and apoptosis Abnormalities in nutrient transport Endocrine function in adolescent damage Tissue remodeling Angiogenesis Placental development | Baker, B.C., et al., [74] | |
Endometrial endometrioid carcinoma | ESRRB mRNA SP7 mRNA GABRB2 mRNA B4GALNT mRNA | Down | Predict lymph node metastasis in endometrial Endometrioid carcinoma | ||
Minimal deviation adenocarcinoma of uterine cervix | Notch1 gene Notch2 gene miR-34b-5p/Notch1 pathway | Down | Promote development of cervical cancer Diagnostic biomarkers | Lee, H., et al., [55] |