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Table 1 Role of miR-34b-5p in multifarious reproductive system diseases

From: Role of microRNA-34b-5p in cancer and injury: how does it work?

Diseases

Gene, mRNA, signal channels, or proteins that may be involved

Variation of miR-34b-5p

Influencing mechanism, effect, or role of miR-34b-5p

References

Ovarian function damage

Ras signaling pathway

Rap1 signaling pathway

Foxo signaling pathway

Hippo signaling pathway

MAPK signaling pathway

Carcinogenic pathway

Down

Cell metabolism regulation post‐transcriptional

Regulation of mRNA interleukin‐6‐mediated

Signal transduction cell cycle

Cell proliferation

Differentiation and migration

Wang, W., et al., [72]

Ovarian cancer

Met gene

c-met gene

Bcl-2 gene

p53 gene

Myc gene

Cdk6 gene

MET protein

BCL-2 protein

CDK4 protein

Down

Regulation of cell death

Occurrence of epithelial ovarian cancer

Development of epithelial ovarian cancer

Metastatic clinical stage

Proliferation and invasion

Cell Proliferation

Cell adhesion-independent growth

 

Spermatogenesis

c-Kit gene

cdk6 gene

Rbm44 gene

Cdh3 gene

CDK6 protein

C-KIT protein

Up in spermatogenesis

Down in decreases in spermatocytes

Cell developmental processes

mRNA transcription and regulation

Cell cycle regulation

Signal transduction

Protein modification

Semen concentration and motility regulation

Sree, S., et al., [76]

Smorag, L., et al., [77]

Eikmans, M., et al., [79]

Placental function

BCL2 gene TP53 gene

MYC gene CDKN1B/C gene

VEGFA gene TNFSF10 gene

ZEB1 gene

Up

Trophoblast proliferation and apoptosis

Abnormalities in nutrient transport

Endocrine function in adolescent damage

Tissue remodeling

Angiogenesis

Placental development

Baker, B.C., et al., [74]

Endometrial endometrioid carcinoma

ESRRB mRNA SP7 mRNA

GABRB2 mRNA

B4GALNT mRNA

Down

Predict lymph node metastasis in endometrial Endometrioid carcinoma

 

Minimal deviation adenocarcinoma of uterine cervix

Notch1 gene Notch2 gene miR-34b-5p/Notch1 pathway

Down

Promote development of cervical cancer Diagnostic biomarkers

Lee, H., et al., [55]

  1. A large number of genes, signaling pathways, and proteins affected by miR-34b-5p have been found in multifarious reproductive system diseases, which are the basic macromolecules of biology, regulating practically all cellular activities and functions