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Fig. 1 | Cancer Cell International

Fig. 1

From: Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors

Fig. 1

The Canonical-Wnt signaling pathway. A In the absence of Wnt, the destruction complex (APC, AXIN, CK1α, and GSK3β) binds and phosphorylates CTNNB1 to mark it for proteasomal degradation. The reduced cytoplasmic level of CTNNB1 leads to the inactivation of Wnt target transcription factors (TCF7, FOSL1, and JUN). B Upon Wnt binding, the destruction complex proteins (APC, AXIN, CK1α, and GSK3β) are recruited to bind FZD and LRP5/6 transmembrane proteins. This will lead to the accumulation of CTNNB1 in the cytoplasm and its translocation to the nucleus. Subsequently, nuclear CTNNB1 binds to Wnt target transcription factors (TCF7, FOSL1, and JUN), leading to gene expression and cell proliferation [5]

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