Fig. 2

Histological analysis of Ctrl and Lyve-1^−/− mice revealed no differences in endothelial differentiation, hepatic metabolic zonation or extracellular matrix deposition. A Immunofluorescence stainings of Ctrl and Lyve-1^−/− livers for CD32b and CD31, Stab2, Icam-1, Lama4 and Desmin (female, n = 5–6/group). Scale bars: 100 µm. B Immunofluorescence stainings of Ctrl and Lyve-1^−/− livers show Glul, Emcn, Arg1, β-Catenin, RhBg, CYP2E1 (female, n = 6/group). Scale bars: 100 µm. C Affymetrix gene microarray (gene chip) analysis of cDNA from LSECs of Ctrl and Lyve-1^−/− mice was performed for gene expression profiling. A dot plot of an overall representation analysis of HALLMARK pathways is presented. The number of regulated genes by count and gene ratio and the adjusted P value of corresponding pathways are presented. Data information: * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001; ns not significant