Fig. 2
From: Ursolic acid: a natural modulator of signaling networks in different cancers
Mechanism of action of Ursolic acid in cancers. Ursolic acid targets numerous molecular players of different cell signaling cascades to promote its anti-cancer potential. It inhibits the activity of Akt, mToR, and ERK, and halts the receptor tyrosine kinase interaction with their respective ligands. It promotes the functioning of Bcl2, BAX, Cytochrome C, and KEAP1. It down-regulates the transcription of MMPs, PD-L1, and VEGF and up-regulates the expression of P27, P21, and Bcl2