Fig. 1
From: Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
Schematic diagram of the vesicles transport process of cargo in endosomal-lysosomal system. Cargo is endocytosed from the cell surface in the form of vesicles with the interaction of the adaptor protein and ESCRTs to the cytoplasm via CME or CIE way. Most vesicles pass through early endosomes, intermediate endosomes and late endosomes via clathrin, and finally be degraded in lysosome, or are also recycled to the plasma membrane by recycle endosomes. Autophagosomes fuse with lysosomes to degrade cellular components, which is origin of autolysosome. Each organelle has its own marker proteins. EE is marked by EEA-1, PI3P and Rab5-GTP. Late endosome is marked by EEA-1, PI3, 5P2 and Rab7-GTP. Intermediate endosome is the fusion of EE and LE, containing the markers of them. Lysosome is marked by Rab7 and Lamp1/2. Autophagosome is marked by ATG14, VAMP8 and STX17