Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system

Table 1 The antitumor drugs targeting the PD-L1 trafficking

Drugs or therapy	Regulatory signal	References
SA-49	PKCα/GSK3β/MITF	[47]
TBM-1	TFEB	[49]
IPAG	Sigma 1	[44]
2-BP	DHHC3	[45]
PD-LYSO	HIP1R	[46]
STM108	EGFR/B3GNT3	[51]
H1A	CMTM6	[43]
Verteporfen	Palmitoylation, glycosylation	[52]
Curcumin	Palmitoylation, glycosylation\STAT\proteasome	[123]
Pitstop 2	Recycle	[124]
Ivermectin	Changes in redistribution, macromolecular interactions	[125]
Diformin	Isolation of PD-L1 in endosomes or autophagosomes	[126]
Amlodipine	Target PD-L1 to lysosome	[127]
LYTAC	Lysosomal targeting chimaera, extracellular proteins	[128]

ISSN: 1475-2867