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Fig. 3 | Cancer Cell International

Fig. 3

From: METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Fig. 3

AKR1B10 promotes glycolysis and the malignant phenotype of CCA cells in vitro. A The overexpression efficacy of METTL3 mRNA expression in RBE cells was confirmed by RT‒qPCR. B The overexpression efficacy of METTL3 protein expression in RBE cells was confirmed by western blot. C The proliferation of RBE cells after overexpression of METTL3 was detected by CCK8. D TUNEL staining was used to detect RBE cell apoptosis after overexpression of METTL3. Scale bar: 50 μm. E The migration and invasion of RBE cells after overexpression of METTL3 were detected by Transwell assays. The numbers of migrating and invading cells were counted for comparison. Scale bar: 100 μm. F Glucose uptake of RBE cells after overexpression of METTL3 was detected using a commercial kit. (G) Lactate production in RBE cells after overexpression of METTL3. **Means P < 0.01, ***means P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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