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Fig. 7 | Cancer Cell International

Fig. 7

From: METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Fig. 7

AKR1B10 promotes glycolysis and the malignant phenotype of CCA cells in vitro. A The knockdown efficacy of two siRNAs against AKR1B10 mRNA expression in RBE cells was confirmed by RT‒qPCR. B The knockdown efficacy of two siRNAs against AKR1B10 protein expression in RBE cells was confirmed by western blot. C The proliferation of RBE cells after AKR1B10 knockdown was detected by CCK8 assay. D Statistical results of Transwell assays. The numbers of migrating and invading cells were counted for comparison. E The migration and invasion of RBE cells after AKR1B10 knockdown were detected by Transwell assays. Scale bar: 100 μm. F Glucose uptake of RBE cells after AKR1B10 knockdown was detected using a commercial kit. G Lactate production in RBE cells after AKR1B10 knockdown. *Means P < 0.05, **means P < 0.01, ***means P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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