Fig. 2

Differential gene expression results in TCGA papillary thyroid tumors, according to TIMP3 expression level. A Volcano Plot of the differentially expressed genes in TIMP3 IV versus I quartile at FDR 1%; blue and red dots show, respectively, 711 down-regulated and 949 up-regulated genes, with a FC of at least 2 in absolute value. B Enrichment plots of selected gene sets that were significantly down-regulated in high versus low TIMP3 expressing tumors by GSEA analysis. Normalized enrichment score (NES), nominal p-value (NOM p-val) and false discovery rate q-value (FDR q-val) are reported for each plot