Fig. 2

Alterations in the expression levels of dystroglycanopathy-associated genes in human tumor cells. The α-DG O-mannosyl glycosylation pathway is depicted, including branches leading to the synthesis of core M1, M2 and M3 glycans. The structure responsible for α-DG interaction with its ECM ligands, matriglycan, is synthesized on the core M3 glycan. Genes and their encoded proteins found to be mostly overexpressed in human solid tumors and cancer-derived established cell lines are indicated in red, and those found in most cases underexpressed are shown in green on their corresponding reactions. GalTs, galactosyltransferases; SiaTs, sialyltransferases