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Table 2 Alterations in dystroglycan expression and glycosylation in human cancer cell lines

From: Involvement of abnormal dystroglycan expression and matriglycan levels in cancer pathogenesis

Alteration

Levels

Tumor type

Cell line

References

DAG1 mRNA

Underexpressed

Acute promyelocytic leukemia (APL)

HL-60

[77, 85]

Acute myeloid leukemia (AML)

Kasumi-1

[77]

α-DG (core) protein

Underexpressed

Glioblastoma

U87MG

[66]

A172MG

APL

HL-60

[77, 85]

AML

Kasumi-1

[77]

α-DG glycosylation

Hypoglycosylated/unglycosylated

Oral squamous cells

SCC-4

[79, 81]

SCC9-, -15, -25

[79]

CAL27

[81]

Esophagus

FLO-1

[82]

Pancreas

PANC-1

[87]

BxPC-3

[87, 103]

Colon

HT29

[100]

LoVo

[104]

Prostate

PC3

[87, 88, 103, 105]

PC3-L

[105]

TEM4-18

[87, 103]

LNCaP

[87, 88, 103, 105]

DU145

[85, 100, 105]

Cervix

HeLa

[69]

Kidney

A498

[103]

Breast

MCF7

[67, 85, 100, 105, 106]

T4-2

[67]

BT549

[85, 106]

MDA-MB-231, −435, −453, −468

[67, 69, 87, 103, 105,106,107]

MDA-MB-134VI, -436

[106]

CAMA1

LY2

HCC38, 70, 1143, 1419, 1500, 1937,  1954

HS578T

AU565

SUM52PE, 149PT, 159PT

ZR75B

Glioblastoma

U87MG

[66, 106]

U251MG

[106]

A172MG

[66]

LN-18

[106, 107]

LN-229

[106]

APL

HL-60

[77, 85]

AML

Kasumi-1

[77]

Melanoma, skin

BLM

[108]

M14

IF6

Rhabdomyosarcoma

PCB82, 232, 380

[96]

Rh18

Lung

H1299

[69]

H2030

β-DG protein

Underexpressed

Esophagus

FLO-1

[82]

Colon

HCT116

[85, 100]

SW620

Prostate

DU145

[85, 88, 100, 109]

Breast

MCF7

[85, 100]

T4-2

[67]

MDA-MB-134VI

[106]

CAMA1

LY2

HCC1419, 1500, 1569, 1954

BT474

APL

HL-60

[77, 85]

AML

Kasumi-1

[77]

Overexpressed

Breast

MCF7

[110]

MDA-MB-453

Melanoma, skin

IF6

[108]

  1. The table compiles all alterations reported so far in human cancer cell lines in the expression of dystroglycan at the mRNA (DAG1 gene) or protein (α- or β-DG subunit) level, or in the glycosylation status of α-DG. The tissue of origin of each cell line and references reporting these results are also indicated