Table 4 Alterations in the expression of dystroglycanopathy-associated genes and proteins in human cancer cell lines
From: Involvement of abnormal dystroglycan expression and matriglycan levels in cancer pathogenesis
Gene | Alteration | Levels | Tumor type | Cell line | References |
|---|---|---|---|---|---|
POMT1 | mRNA | Underexpressed | Colon | HCT116 | [136] |
Acute promyelocytic leukemia (APL) | HL-60 | [77] | |||
Acute myeloid leukemia (AML) | Kasumi-1 | ||||
POMT2 | mRNA | Underexpressed | Stomach | Kato III | [137] |
Breast | MCF7 | [111] | |||
MDA-MB-231, -453 | |||||
T47D | |||||
APL | HL-60 | [77] | |||
AML | Kasumi-1 | ||||
Protein | Underexpressed | Stomach | Kato III | [137] | |
DPM1 | mRNA | Overexpressed | Liver | Hep G2 | [113] |
SMMC-7721 | |||||
DPM2 | mRNA | Overexpressed | Liver | SMMC-7721 | [113] |
DPM3 | mRNA | Overexpressed | Liver | SMMC-7721 | [113] |
POMGNT1 | mRNA | Underexpressed | APL | HL-60 | [77] |
AML | Kasumi-1 | ||||
B3GALNT2 | mRNA | Underexpressed | Liver | BEL-7405 | [117] |
Overexpressed | Liver | Huh7 | |||
Hepa 3B | |||||
Hep G2 | |||||
SMMC-7721 | |||||
BEL-7402, 7404 | |||||
Breast | MDA-MB-453 | [118] | |||
HCC1143, 1395, 1599 | |||||
T47D | |||||
BT-20 | |||||
ZR-75-1 | |||||
OCUB-F | |||||
Protein | Overexpressed | Liver | Huh7 | [117] | |
Hepa 3B | |||||
Hep G2 | |||||
SMMC-7721 | |||||
BEL-7402, -7404, -7405 | |||||
FKTN | mRNA | Underexpressed | APL | HL-60 | [77] |
AML | Kasumi-1 | ||||
Overexpressed | Stomach | MKN-1, 45 | [121] | ||
Protein | Underexpressed | Cervix | HeLa | [138] | |
Overexpressed | Stomach | MKN-1, 45 | [121] | ||
HSC-57 | |||||
FKRP | mRNA | Underexpressed | APL | HL-60 | [77] |
AML | Kasumi-1 | ||||
B4GAT1 | mRNA | Underexpressed | Prostate | PC3 | [105] |
PC3-L | |||||
LNCaP | |||||
Breast | MDA-MB-231, -435 | ||||
LARGE1 | mRNA | Overexpressed | Liver | Huh7 | [127] |
Hep G2 | |||||
SMMC-7721 | |||||
Underexpressed | Oral squamous cells | SCC-4 | [81] | ||
CAL27 | |||||
Pancreas | PANC-1 | [87] | |||
BxPC-3 | |||||
Prostate | PC3 | [87] | |||
Cervix | HeLa | [69] | |||
Breast | MDA-MB-231, -436, 468 | ||||
HCC38, 70, 1143, 1500, 1937 | [106] | ||||
SUM149-PT, 159PT | |||||
Glioblastoma | U87MG | [106] | |||
U251MG | |||||
LN-18 | |||||
APL | HL-60 | [77] | |||
AML | Kasumi-1 | ||||
Rhabdomyosarcoma | Rh18 | [96] | |||
Lung | H1299 | [69] | |||
H2030 | |||||
Protein | Underexpressed | Breast | MDA-MB-231 | [107] | |
Glioblastoma | U87MG | [106] | |||
U251MG | |||||
LN-18 | |||||
LARGE2 | mRNA | Underexpressed | Pancreas | PANC-1 | [87] |
BxPC-3 | |||||
Colon | HT-29 | [87] | |||
Colo205 | |||||
RKO | |||||
Prostate | TEM4-18 | ||||
Kidney | A498 | [103] | |||
Breast | MDA-MB-231 | ||||
ZR-75-1 | [87] | ||||
Overexpressed | Colon | SW480, 620 | [128] | ||
LS174T |