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Fig. 1 | Cancer Cell International

Fig. 1

From: BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture

Fig. 1

The effect of BI-847325 on the expression of different inspected genes in C643 and SW1736 ATC cell lines. A The expression of AURKA, MDR1, MRP1, NFκB2, and VEGF genes was significantly decreased in C643 cell line. The expression of P16 and BIM as well as NIS and Tg genes was significantly increased in this cell line. All the expressions were compared to the untreated control 48 h after treatment with 15 µM of BI-847325. B The expression of AURKA, AURKB, MDR1, MRP1, NFκB1, NFκB2, and VEGF genes was significantly decreased in SW1736 cell line. The expression of P16 and BIM as well as NIS and Tg genes was significantly increased in this cell line. All the expressions were compared to the untreated control 48 h after treatment with 34 µM of BI-847325. Statistical significances are expressed as p < .05 (*); p < .01 (**); p < .001 (***); p < .0001 (****). C Gplot heatmap of gene expression data in C643 and SW1736 ATC cell lines. The differences between the gene expression profile of AURKA, AURKB, MDR1, MRP1, NFκB1, NFκB2, VEGF, P16, BIM, NIS, and Tg in C643 and SW1736 are shown as color-coded: crimson for upregulated and dark blue for downregulated genes

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