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Fig. 4 | Cancer Cell International

Fig. 4

From: BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture

Fig. 4

The effect of BI-847325 on invasion of ATC cell lines as well as inhibition of the kinases function of MEK1/2 and AURKB. Alexa Fluor 549 Phalloidin staining was performed to investigate changes in the invasiveness of C643 A and SW1736 B 48 h after BI-847325 treatment. The nuclei were also stained simultaneously with DAPI (A-B, magnification = 400X, Scale bar = 50 μm). C The proportion of cell invading is indicated for C643 and SW1736. Statistical significances are expressed as p < .05 (*); p < .01 (**); p < .001 (***); p < .0001 (****). D This hybrid compound decreased the function of MEK1/2 and AURKB by reducing the levels of phospho-ERK1/2 and phospho-Histone H3 in C643 and SW1736 cell lines. Uncropped immunoblots are shown in Additional file 1: Fig. S1

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Cancer Cell International

ISSN: 1475-2867

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