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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA HOTAIR impairs the prognosis of papillary thyroid cancer via regulating cellular malignancy and epigenetically suppressing DLX1

Fig. 4

DLX1 was negatively correlated with HOTAIR and epigenetically regulated by HOTAIR. A Correlation between DLX1 and HOTAIR expression in PTC tissues was plotted and analyzed with Pearson’s correlation. B Relative DLX1 expression was measured by real-time qPCR and compared between four PTC cell lines (n = 3). C Correlation between HOTAIR and DLX1 expression was assessed among four PTC cell lines (n = 3). D DLX1 was blotted on Scramble/si-HOTAIR and Control/HOTAIR-OE cells to quantify its relative protein levels after regulating HOTAIR expression (n = 3). E EZH2 (n = 5) and H3K27me3 (n = 3) chromatin immunoprecipitation were performed on Scramble and si-HOTAIR cells. Data are presented as means ± SD. Statistical significance was assessed using paired or independent Student T-test; Mann–Whitney U test to examine the differential %Input between two cells, *p < 0.05; **p < 0.01; ***p < 0.001

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