Fig. 2
From: Targeting hyaluronic acid synthase-3 (HAS3) for the treatment of advanced renal cell carcinoma
Measurement of HAS3 levels in normal and RCC tissues and their association with the clinical outcome. A, B: HAS3 transcript levels were measured in normal kidney (NK) and RCC tissues and normalized to TBP transcript levels. A: Data were stratified for NK, oncocytoma, clear cell (cc) and non-cc RCC (papillary, chromophobe, collecting duct, sarcomatoid) tissues. B: transcript data for RCC tissues were stratified based on the development of metastasis during follow-up. C, D: HAS3 protein expression (C) and HA levels in NK and RCC tissues based on the patients’ metastasis status during follow-up. Loading control: Actin. The images are cropped for brevity. Uncropped images of the blots shown in panel C are provided in the Additional file 1 (Appendix). Data: Mean ± SD (D). E–G: Stratification of the cohorts for metastasis (clinical; panel E) and OS (TCGA-KIRC, TCGA-KIRP; panels F, G) based on HAS3 mRNA levels. P values based on the log-rank test