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Table 1 IC50 values for the cytotoxicity of SF or SF plus combination

From: Targeting hyaluronic acid synthase-3 (HAS3) for the treatment of advanced renal cell carcinoma

Transfectant

SF IC50 for EV/HAS3 transfectants

0 mM MU

0.1 mM MU

0.2 mM MU

786-O EV

8.586

4.405

1.201

786-O HAS3

9.736

7.897

7.254

Caki-1 EV

8.216

5.544

2.912

Caki-1 HAS3

9.043

9.194

7.266

SF IC50 for shRNA transfectants

 

Ctrl

HAS3 # 1

HAS3 # 2

786-O

8.386

1.974

3.049

Caki-1

7.385

3.120

2.792

  1. IC50 values were calculated from the non-linear regression analysis of dose–response curves using the sigmoidal dose–response (variable slope) equation